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Codeine used to treat mild to moderate pain, cough, and diarrhea. It is made from opium or morphine. Codeine phosphate works by binding to mu opioid receptors on cells in the central nervous system. This blocks pain signals and changes how the body responds to pain. It also helps decrease activity in the part of the brain that causes coughing. When used for diarrhea, it slows the movement of the muscles in the intestines, giving the body more time